MHSI

Call for an appointment

(877) 784-3667

Our Physicians

need_appointment_default

rx_refil_default

join_maillist_default

Mick Perez-Cruet, M.D.

Introduction: Lumbar spinal fusion surgery is performed to alleviated debilitating back pain symptoms due to a variety of spinal conditions including spondylolisthesis with or without spinal stenosis. Sources of bone graft can include autograph, allograft or bone substitutes. The BoneBac Press (Thompson MIS, Salem, NH) was developed to collect drilled local bone collected during the decompression and or approach (Figs. 1-3). This study analyzed the cost savings and effectiveness of collecting local bone, need for additional allograft, and fusion rates while preforming minimally invasive transforaminal lumbar interbody fusion (MITLIF).

Methods: A retrospective analysis was preformed of 93 patients who received MITLIF (using Thompson MIS TLIF system). One level MITLIF was preformed using the in 95% of patients. The amount of local autography collected using the BoneBac Press was recorded. The amount of additional allograph supplement was also recorded for each case and the ratio of autograph to allograph used (Figs. 4-8). The cost of each surgery was estimated based on the allograph savings.

Mick Perez-Cruet, M.D.

Introduction: Intervertebral disc (IVD) degeneration is characterized by the loss of nucleus pulposus (NP) leading to disc space collapse which is a common cause of low back pain (Fig. 1). Currently, degenerative disc disease (DDD) has no biological cure and human stem cell therapy is increasingly being considered for its treatment. However, stem cells alone may not be adequate to provide bio-mechanical disc height restoration. Disc restorative technology is being investigated that might restore the bio-mechanical function of the degenerated disc via a process of gradual tissue growth generated distraction (TGGD). Once disc height is restored the injection of nucleus pulposus cells (NPCs) can restore the biological function of the degenerated disc.

Methods: In this study, we investigated the feasibility of human umbilical cord mesenchymal stem cells (UC-MSCs) differentiated into NPCs invitro in an in-vivo rabbit model of DDD (Fig. 2). Histological, biochemical and gene expression analysis was preformed to determine the optimal cell for NP regeneration (Fig.3). Further finite element analysis was preformed of a mechanical technology called Annulo (MI4Spine LLC, Bloomfield, MI) used to achieve disc height restoration.

Mick Perez-Cruet, M.D., M.S.

Introduction:  Long-term prospective outcomes in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MITLIF) for debilitating back pain has not been well studied.

Methods:  318 patients (mean age 63, range 19-94) who underwent MITLIF with an average 5 year follow-up (range1 to 7 years), treated for spondylolisthesis (236, 74%) or degenerative disc disease (82, 26%) causing intractable back pain. Health care quality of life measures included visual analog scale (VAS), oswestry disability index (ODI), and short from (SF-36).

Mick Perez-Cruet, M.D.

Introduction: Degenerative disc disease (DDD) is a common spinal disorder that manifests with lower back pain (Fig. 1). The degeneration of intervertebral disc (IVD) is characterized by the loss of extracellular matrix and dehydration of the nucleus pulposus (NP) of IVDs (Fig. 2). Currently, there is no biological treatment to cure this debilitating ailment.

Methods: We investigated the efficacy of NP-like cells (NPCs) derived from the umbilical cord (UC) MSCs in restoring degenerated IVDs using a rabbit DDD model (Fig. 3). UC -MSCs were induced to differentiate into NPCs by using differentiation medium (DM) for two weeks, labeled with PKH26 and then injected into the degenerated IVDs (Fig. 4-5).

Mick J. Perez-Cruet M.D., M.S.

Long-term prospective outcomes in patients undergoing minimally-invasive spinal fusion for debilitating back pain have not been well studied. 

318 patients (mean age 63 years, range 19-94) who underwent MITLIF were followed over 7 years. Patients presented with spondylolisthesis (n = 236,

74%), and degenerative disc disease (n = 82, 26%). Health care quality of life measures studied were Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Short Form-36 (SF36) for 7 years. Other outcomes analyzed included pre- operative co-morbidities, age, bone quality, and complications.

Our Physicians

need_appointment_default

rx_refil_default

join_maillist_default

EXPERTISE makes the difference

  We will will be closed on Monday, December 25 & 26, 2017 and January 1 & 2, 2018, please submit Rx refills prior to those dates.      We are experiencing very high call volumes, please use the Appointment Request, Contact Us, or Rx Refill by clicking on the words or use the buttons above.  Thank you for your patience as we roll out the new EHR system beginning Aug. 28...for more information click here.  ALL patients will be required to resubmit information, prior to their next appointment.